Clinical diagnosis : the bacteriological, chemical, and microscopical evidence of disease . LOOD Finally (and this, in the authors opinion, is the commonest case), thepigment particles, both small and large, may he enclosed within cellswhich occasionally resemble white blood-corpuscles, and sometimes differfrom them in being flask- or spindle-shaped. The pigment lumps arevery rarely observed; but, on the other hand, the granules, and, morecommonly still, pigment-laden white corpuscles, are often temporarilypresent after a severe attack of ague and in relapsing fever. Thepreparation (shown in f
Clinical diagnosis : the bacteriological, chemical, and microscopical evidence of disease . LOOD Finally (and this, in the authors opinion, is the commonest case), thepigment particles, both small and large, may he enclosed within cellswhich occasionally resemble white blood-corpuscles, and sometimes differfrom them in being flask- or spindle-shaped. The pigment lumps arevery rarely observed; but, on the other hand, the granules, and, morecommonly still, pigment-laden white corpuscles, are often temporarilypresent after a severe attack of ague and in relapsing fever. Thepreparation (shown in fig. 19) was made from the blood of a man whohad suffered for a year from malarial disease which he had contracted inthe tropics. The appearances described here are usually associated witholigochromasia and oligocythemia, and accompanied by the symptomsof anaemia (compare p. 44). 6. MicrOCythtBIttia.—This condition was first described by Vanlairand It is characterised by the presence in the blood of smallhemoglobin-containing elements {microcytes), which are probably derived. Fig. ig.—Melansemic Blood (eye-piece III., objective 8A, Reichert), from a Case ofMalarial Cachexia. from the red blood-cells, and are generally smaller, but occasionally larger(megaloblasts of Hay em and Ehrlich), than these. Such bodies are found in many morbid states, and notably in toxicstates, infectious diseases, pronounced anaemia, and in burns. Notwith-standing that much has been written about them, there is really butlittle known on the subject of microcytes, and their discovery is ofno assistance in diagnosis. Litten has shown that they may rapidlyappear in the blood, and as rapidly disappear from it. We may referhere also to BettelJieims162 observations on the subject of minute mobilegranules in the blood. Gram and Graber163 regard the microcytes asthe result of post-mortem changes in the blood. The latter believes thatthey represent the final product of the rapid and uniform abstr
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