. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . ly shut off from the circulation and perfusedwith warm oxygenated Ringers solution. Injection of 1,5 cc. of1: 20,000 adrenahn into the jugular vein caused sUght dilatation ofthe perfused limb, while after twice the dose the dilatation was second animal was studied after destruction of the fast five lumbarand the first two sacral sympathetic ganglia. The dilatation from 174 F, A. HARTMAN, L. G. KILBORN AND L, FRASER adrenalin was very great (fig. 4). In a third dog both sympatheticchains were completely destroye
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . ly shut off from the circulation and perfusedwith warm oxygenated Ringers solution. Injection of 1,5 cc. of1: 20,000 adrenahn into the jugular vein caused sUght dilatation ofthe perfused limb, while after twice the dose the dilatation was second animal was studied after destruction of the fast five lumbarand the first two sacral sympathetic ganglia. The dilatation from 174 F, A. HARTMAN, L. G. KILBORN AND L, FRASER adrenalin was very great (fig. 4). In a third dog both sympatheticchains were completely destroyed on both sides from the third lumbarganglion downward. Adrenalin, injected into the general circulation,caused the perfused limb to dilate as in the other experiments. Theanimals were always examined at the completion of the experiments toascertain the limit of gangliar destruction. These experiments made it appear that the limb mechanism wasnot in the sympathetic ganglia but in those of the dorsal roots. Todetermine this we approached the question in another wlay. The. Fig. 4. Dilatation in the perfused hind limb of a dog (weight kgm.) fromthe injection of 4 cc, 1: 20,000 adrenalin into the jugular vein, after removingthe last five lumbar and the first two sacral sympathetic ganglia on the sameside. Base of bellows 10 mm. x 19 mm. (Reduced one-half.) dorsal and ventral roots of all lumbar and sacral nerves were cut centralto the dorsal root gangha on the right side. The right hind limb,after being placed in a plethysmograph, was completely cut off fromthe general circulation and immediately perfused. Adrenalin injectedinto the jugular vein caused dilatation of the perfused hmb. Thenext step was removal of all dorsal root ganglia supplying the perfusedlimb. Following this operation injection of adrenahn into the jugularvein produced an effect on the perfused limb similar to that occurringbefore removal of the ganglia (see fig. 5). This was repeated in threedogs with the s
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