. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. Vol. 96, No. 1 February, 1949 THE BIOLOGICAL BULLETIN PUBLISHED BY THE MARINE BIOLOGICAL LABORATORY. A i-l- EFFECT OF UREA, THIOUREA, PHENYLTHIOUREA AND THIOURACIL ON THE OXYGEN CONSUMPTION OF BLOCKED AND ACTIVE EMBRYONIC CELLS 1 JOSEPH HALL BODINE AND LAURENCE ROCKWELL FITZGERALD Zoological Laboratory, State University of loiva, loiva City, loiva INTRODUCTION Considerable data on the action of urea, thiourea, thiouracil and related com- pounds on the intact organism are at hand, especially as regards their action in such ph
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. Vol. 96, No. 1 February, 1949 THE BIOLOGICAL BULLETIN PUBLISHED BY THE MARINE BIOLOGICAL LABORATORY. A i-l- EFFECT OF UREA, THIOUREA, PHENYLTHIOUREA AND THIOURACIL ON THE OXYGEN CONSUMPTION OF BLOCKED AND ACTIVE EMBRYONIC CELLS 1 JOSEPH HALL BODINE AND LAURENCE ROCKWELL FITZGERALD Zoological Laboratory, State University of loiva, loiva City, loiva INTRODUCTION Considerable data on the action of urea, thiourea, thiouracil and related com- pounds on the intact organism are at hand, especially as regards their action in such phenomena as growth and thyroid function (Lynn, 1948). That thiourea and thiouracil are important in the activity of the thyroid gland has been widely demonstrated both clinically and otherwise. The exact mechanism of their ac- j tion on cells, however, seems to be less well understood. The fact that certain oxidations, involving cytochrome-cytochrome oxidase or the peroxidase systems. are significant in the reactions of thiourea and thiouracil seems well established (Sadhu, 1948). It becomes of some interest, therefore, to compare the effects of such chemicals upon the respiratory mechanisms of embryonic cells, both in the mitotically active as well as in the resting or blocked condition. The present paper has to do with results of studies on the effects of urea, thiourea, phenyl- thiourea and thiouracil upon the oxygen uptake of mitotically active and blocked cells of the embryo of the grasshopper, Mclanoplns diffcrcntialis. MATERIALS AND METHODS Eggs of the grasshopper, Mclanoplns diffcrcntialis, were obtained and dis- section of embryos carried out as previously noted (Bodine and Boell, 1934). Sterile phosphate-buffered Ringer solution (pH ) was used as the suspending medium for the embryos. All solutions of chemicals (—urea, thiourea, phenyl- thiourea, thiouracil2) were made up in this buffered Ringer solution. Diapause (blocked) and post-diapause (active) embryos w
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
