. The actinomycetes. Actinomycetales. -OH The nitrogen is present in the form of an studied chiefly by Borowski and coworkers amino group in a five-carbon sugar moiety, (1960). Amphotericin B and candidin are mycosamine. A large lactone ring of the xevy closely related substances, each of type found in the bacterial macrolides, such which contains one atom of nitrogen located as erythromycin, is formed in part by the in the amino sugar, mycosamine. In contrast, tetraenic chromophore. A carl)oxyl and an candicidin, trichomycin, and perimycin have epoxide group are attached to the large twoamino
. The actinomycetes. Actinomycetales. -OH The nitrogen is present in the form of an studied chiefly by Borowski and coworkers amino group in a five-carbon sugar moiety, (1960). Amphotericin B and candidin are mycosamine. A large lactone ring of the xevy closely related substances, each of type found in the bacterial macrolides, such which contains one atom of nitrogen located as erythromycin, is formed in part by the in the amino sugar, mycosamine. In contrast, tetraenic chromophore. A carl)oxyl and an candicidin, trichomycin, and perimycin have epoxide group are attached to the large twoaminogroupsper molecule. In candicidin lactone ring. Alycosamine is also present in and trichomycin, one of these amino groups the molecule of another tetraene, nystatin, is located in a mycosamine moiety and the and in the molecule of some of the hep- other in a p-aminoacetophenone moiety: taenes. Nystatin has a larger molecule than pimaricin; it has the empirical formula Lagosin and filipin are two pentaenes which do not contain nitrogen: CH3(CH2)4CHOH CHa—CO—r ^—NH2 Perimycin dilTers in that one of the amino groups is located in an amino sugar moiety. OH Lagosin: R = OH The large lactone ring of each is formed of 27 carbons and includes the pentaenic chromophore. Other pentaenes, such as antibiotic PA 1").'^, contain nitrogen. The hexaenes are the least known poly- enes. They have not been isolated as often as the tetraenes, the pentaenes, and the OH Filii)iii: of unknown structure and the other is in a p-aminophenylacetone moiety: CH,—CO—CH,,- -NH2 Perimycin, unlike other heptaenes, does not have a carboxyl group. With the help of the keys, sunnnaries of. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Waksman, Selman A. (Selman Abraham), 1888-1973. Baltimore, Williams & Wilkins
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