. The Biochemical journal, 1918. Biochemistry. ANTI-SCORBUTIC VALUE OF COWS MILK i;{; factor (anti-bcri-bcri or anti-nouritic vitauiino) protecting from avian polyneuritis and human beri-beri. McCollum and his co-workers do not admit that there is an additional factor pro- tecting from scurvy. It is however possible that had their work been carried out with anrtthcr experimental animal they might have reached another ef)nelusion. It i» well known that the rat is insusceptible to scurvy, and it may well l)e that it re(|uireH only a small amount of the anti- scorbutic factor and that sufHcient t
. The Biochemical journal, 1918. Biochemistry. ANTI-SCORBUTIC VALUE OF COWS MILK i;{; factor (anti-bcri-bcri or anti-nouritic vitauiino) protecting from avian polyneuritis and human beri-beri. McCollum and his co-workers do not admit that there is an additional factor pro- tecting from scurvy. It is however possible that had their work been carried out with anrtthcr experimental animal they might have reached another ef)nelusion. It i» well known that the rat is insusceptible to scurvy, and it may well l)e that it re(|uireH only a small amount of the anti- scorbutic factor and that sufHcient traces may remain in the substances of animal and plant origin which supply the two "growth" factors. Our work leaves us in no doubt that, in the case of guinea-pigs and man, an accessory anti- scorbutic factor is required to maintain health. Although in many cases growth will cease in young animals if tJiis anti-scorbutics factor is omitted from the rliet, it does not appear likely from a study of their respective distributions that this anti-scurvy vitamine is identical with either of the two growth factors described by the American workers. In our own experiments, the anti-beri-beri vitamine (probably identical with the growth factor "Water Soluble B") is present in abundance in the ample ration provided of whole oats and wheaten bran. The second growth factor, "Fat Soluble A," may be operating in our milk ration (even when strongly heated) and is distinct from the anti-scurvy accessory 15 20 25 30 35 40 Chart 2. Wciuht curve of young guinea-pigs upon a diet of oats and i)ran (ad lib.) and auto- claved (1 hour at 120° C.) cow's milk up to 60 cc. daily, sec Table II, Expts l-(j. • — . signifies normal weight curve upon a diet of oats and bran and fresh cabbage ad Uh. ts signifies death from scurvy, f Cure signifies cure begun with fruit juice. It is necessary to give a short description of what is meant in the Tables by "scurvy
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