The pathology and surgical treatment of tumors . ofconnective-tissue fibrils and the fibrillated prolongations of the spindle-cells possess the maximum power of fibrillation. In sec-tions in which the cells have been brushed out the reticular spaces arenot empty, as in carcinoma, but contain a network of the finest large spindle-celled sarcoma is usually softer than tumors com-posed of small spindle-cells. Spindle-celled sarcoma grows lessrapidly than tumors composed of other histological varieties of degree of mahgnancy is determined by the abundance of thes
The pathology and surgical treatment of tumors . ofconnective-tissue fibrils and the fibrillated prolongations of the spindle-cells possess the maximum power of fibrillation. In sec-tions in which the cells have been brushed out the reticular spaces arenot empty, as in carcinoma, but contain a network of the finest large spindle-celled sarcoma is usually softer than tumors com-posed of small spindle-cells. Spindle-celled sarcoma grows lessrapidly than tumors composed of other histological varieties of degree of mahgnancy is determined by the abundance of thestroma. If the connective-tissue stroma is well developed, the tumoris hard and grows slowly; if the stroma is scanty, the tumor is corre-spondingly soft and more malignant. Giant-celled Sarcoma.—This tumor consists of various forms of cells,of which the large, many-nucleated cell, resembling the myeloplaquesor osteoclasts in the bone, is the prototype. Giant-celled sarcomaarises pre-eminently from bone (Fig. 388), but similar tumors are also. Fig. 388.—Giant-celled sarcoma from upper jaw; X 230 (after Perls). found in other tissues. In bone, giant-cells, the myeloplaques ofRobin, are found in a normal condition. According to Kolliker, thesecells act the part of osteoclasts, or bone-destroyers. In connectionwith bone giant-celled sarcomata occur as tumors which are clinicallyvery different from one another. The periosteal form is most frequentlyfound in the alveolar sockets of the teeth (epulis), where the tumors 540 PATHOLOGY AND TREATMENT OF TUMORS. manifest the lowest degree of malignancy. The myelogenous form isproductive of early metastasis—an occurrence which often takes placebefore the primary tumor is detected. The so-called maHgnant epulis is composed mostly of spindle-cells (and between them, here and there,a giant-cell with multiple nuclei in the centre of the cells) and round-cells (Fig. 389). If such a tumor is carefully examined, it will be seen v-^.^
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Keywords: ., bookcentury1800, bookdecade1890, booksubjectneoplas, bookyear1895
