. Electron microscopy; proceedings of the Stockholm Conference, September, 1956. Electron microscopy. The Ultrastructure of the Thyroid Gland of the Mouse R. Ekholm and F. S. Sjostrand The Laboratory for Biological I'ltrastriictiirc Research of the Departnicm o/ Anuioiiiy. hciro/iiiskci , Stockholm, ami the Department of Anatomy, University of Gothenburg This paper presents the results obtained mainly by studying the thyroid gland of mice kept in normal laboratory conditions. These results will be the basis of a further analysis of the structural changes in the thyroid in connectio
. Electron microscopy; proceedings of the Stockholm Conference, September, 1956. Electron microscopy. The Ultrastructure of the Thyroid Gland of the Mouse R. Ekholm and F. S. Sjostrand The Laboratory for Biological I'ltrastriictiirc Research of the Departnicm o/ Anuioiiiy. hciro/iiiskci , Stockholm, ami the Department of Anatomy, University of Gothenburg This paper presents the results obtained mainly by studying the thyroid gland of mice kept in normal laboratory conditions. These results will be the basis of a further analysis of the structural changes in the thyroid in connection with the stimulating and inactivating of the gland. The thyroid has earlier been studied with aid of the electron microscope by several investigators (1,2, 4). The observations made by these authors are in general accord. Thus, they all give an account of the existence of microvilli on the follicular surface of the thyroid cells and a "lamellar"" or "canalicular"" structure in the cytoplasm. However, as regards the structure of the capillaries, opinions are at variance. Monroe suggests that, in places, the endothelium lining of the capillaries is discontinuous but Demp- sey and Peterson are of the opinion that close exa- mination always reveals a continuous capillary wall. Material and methods.—The thyroid gland of 40 adult white mice were examined. The fixation of the tissue specimens was performed in a blood isolon 1 per cent osmium tetroxide soliilion, butVered at pH with veronal acetate, a modification of the osmium solution of Palade (6). The specimens were embedded in a mixture of /;-biityl and /;-methyl niethacrvlate mainly according to Newman et al. The uluathin sectioning was perft)rmed partly with the microtome designed by Sjostrand (7), partly with an instrument described by Kkholm &Zelan- der (3). The sections were examined partiv in an RCA EMU 2b, partly in an RCA EMU 3b microscope. Results.—The thyroid cells are organize
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