. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . fortunately the horse which we used was in suchpoor condition that it cannot be considered was anaesthetized with chloroform, and 1:1000adrenalin was injected in every instance. In no casewas there a fall in blood pressure. cc, adrenalinchanged the pressure from 114 mm. to 162 mm. HARTMAN, KILBORN AND LANG 129 increased the pressure from 80 to 260 mm. Attempts to produce dilatation of the intestinewere successful when was injected, therebeing a strong constriction followed by a dilatat
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . fortunately the horse which we used was in suchpoor condition that it cannot be considered was anaesthetized with chloroform, and 1:1000adrenalin was injected in every instance. In no casewas there a fall in blood pressure. cc, adrenalinchanged the pressure from 114 mm. to 162 mm. HARTMAN, KILBORN AND LANG 129 increased the pressure from 80 to 260 mm. Attempts to produce dilatation of the intestinewere successful when was injected, therebeing a strong constriction followed by a produced constriction only. Intestinal dilatation was the only indication of thepresence of an adrenalin vasodilator mechanism in the horse. Artiodactyla (Capra)In vieAY of the unsatisfactory condition of thehorse, it was imperative that another animal belong-ing to the ungulates be tried. An experiment witha goat (weight kgm.) removed all doubt as tothe existence of adrenalin vasodilator mechanisms inthis order. A depressor effect (Fig. 6) as well as. FIG. 6Fall in blood pressure from , 1:100,000 adrenalin in thegoat, kgm. (Reduced V2.) active dilatation of the limb (Fig. 7) could be ob-tained from the injection of small amounts of adren-alin. However nothing but constriction in the intes-tine (Fig. 8) resulted from even large doses of adren-alin until perfusion was attempted. A loop of intes-rine, Avith nerves intact, but shut off from the generalcirculation and perfused with oxygenated Ringerssolution gave pronounced dilatation both when 130 ADRENALIN IN VERTEBRATES
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