. Endocrinology. Fig-. 9. Breast at time of operation. X marks nipple. When we analyze our results we find that the injection ofthe several above-mentioned commercial preparations are unableto prevent the atrophy that follows castration in rabbits. Theamounts given are easily the equivalent of the dosage exhibitedto human subjects, and we conclude that there is nothing inthese preparations, sufficiently active, that will substitute for. Fig:. 10. Same animal as Fig. 9, 60 days after castration; 25 injec-tions of Parke-Davis Ovarian Residue. Breast showing marked atrophywith absence of secretin
. Endocrinology. Fig-. 9. Breast at time of operation. X marks nipple. When we analyze our results we find that the injection ofthe several above-mentioned commercial preparations are unableto prevent the atrophy that follows castration in rabbits. Theamounts given are easily the equivalent of the dosage exhibitedto human subjects, and we conclude that there is nothing inthese preparations, sufficiently active, that will substitute for. Fig:. 10. Same animal as Fig. 9, 60 days after castration; 25 injec-tions of Parke-Davis Ovarian Residue. Breast showing marked atrophywith absence of secreting glands and atrophy of nipple. X marks nipple. the hormone that normally maintains the nutrition of the these preparations represent all the active epithelial elementsof the ovary, we can say that the active or substancesare not solely situated in the ovary or that they may be destroyedin the preparation. 00 VALUE OF OVARIAN EXTRACTS The cervix does not take part in this atrophy and it wouldappear more reasonable to suppose, not that the material usedwas the active factor in maintaining its normal status, but thatthe castration does not affect it. as can bo demonstrated in ourcontrols. Adrenal with focal areas of pale granular ce The breasts likewise undergo a complete atrophy which can-not be inhibited by the use of these commercial glandular ex-tracts. This same atrophy takes place in the castrates not in
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Keywords: ., bookcentury1900, bookdecade1910, booksubjectendocrinology, bookye
