. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . Fig. 8. Constriction of kidney after a dose of adrenalin cc, 1 : 100,000 (Re-duced i) was the only effect (see fig. 8); in two cases the preliminary constric-tion caused by large doses (, cc. 1 : 100,000 per kilogram),such as occasioned a preliminary rise followed by a fall of bloodpressure, was followed by a dilatation of the organ. The curve ofthis dilatation was similar in form to that familiar to us in the reac-tion of the intestine to large doses of adrenalin. It showed a rise of DIFFERENTIAL ACTION OF
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . Fig. 8. Constriction of kidney after a dose of adrenalin cc, 1 : 100,000 (Re-duced i) was the only effect (see fig. 8); in two cases the preliminary constric-tion caused by large doses (, cc. 1 : 100,000 per kilogram),such as occasioned a preliminary rise followed by a fall of bloodpressure, was followed by a dilatation of the organ. The curve ofthis dilatation was similar in form to that familiar to us in the reac-tion of the intestine to large doses of adrenalin. It showed a rise of DIFFERENTIAL ACTION OF ADRENALIN 321. 322 FRANK A. HARTMAN AND LOIS MCPHEDRAN the lever, which only gradually returned to the base line, not before170 to 180 seconds had elapsed, and thus continued long after theblood pressure had regained its normal level. The cuase of the occur-rence of this dilatation we were not able to determine. In conclusion we wish to point out that the reactions of the variousorgans, though they may be of a similar nature, do not. necessarilytake place at the same time, nor for the same dose. Thus, for in-stance, in dog 23, table 2, though both kidney and intestine give con-striction in response to small doses and dilatation in response to largeones, nevertheless that dose of adrenalin ( cc, 1:100,000 per kilogram)which is enough to cause transition from a dilatation to a constrictionin the intestine, still gives rise to nothing but a constriction in thekidney. Numerous other examples may be found by reference to thattable. That the output of adrenalin, which has been shown by the workof the l
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