. The thyroid gland in health and disease. s two or three during one month. I The blood-serum of thyroidectomized dogs is more toxic than normal serumand gives rise to convulsions when injected into healthy dogs (Gley). The urineof such animals also contains a higher percentage of toxic substances than isnormal, and thyroid extract administered to them counteracts this toxicity (deLuca and dAngerio).—R. McC. INFLUENCE OF GOITRE IN THE MOTHER 129 There is no unconsciousness during them. She has long beenmyxoedematous, but beheves that she is better than she used to gives a very goitrous
. The thyroid gland in health and disease. s two or three during one month. I The blood-serum of thyroidectomized dogs is more toxic than normal serumand gives rise to convulsions when injected into healthy dogs (Gley). The urineof such animals also contains a higher percentage of toxic substances than isnormal, and thyroid extract administered to them counteracts this toxicity (deLuca and dAngerio).—R. McC. INFLUENCE OF GOITRE IN THE MOTHER 129 There is no unconsciousness during them. She has long beenmyxoedematous, but beheves that she is better than she used to gives a very goitrous and myxoedematous family has had eight children before the present child. They wereall, according to her, born cretins. All were very swollen frombirth, and all died before the age of 3. The child shown in thephotograph is aged 2. It was remarkably swollen, but improvedvery decidedly under thyroid feeding. Nos. 190 and 191.—Family very poor. Mother has a largetumorous goitre and suffers from tetany during pregnancy; she is. Fia. 56.—Myxoedematous mother with her cretinous child. coarse-skinned and somewhat swollen. Her son, aged 24 (fig. 57),is a typical nervous cretin of an extreme degree ; he is a daughter is a typical myxoedematous cretin, aged 18, whosehearing and speech are defective. The mother has had nine children,of whom four are alive; all show signs of cretinism, the twoyoungest in lesser degree than the two eldest just described. Thefather has a large tumorous goitre. No. 82.—Mother has had three perfectly healthy children. Shethen developed goitre, and subsequently gave birth to the presentchild, who became a cretin after a convulsive fit when aged 2. Thiscretin is aged 20 and is very swollen. 9 130 ENDEMIC CRETINISM The influence of goitre in the male parent is difficult toappraise. It seems likely, however, that it may be of someimportance in transmitting a hereditary goitrous taint. II. Psychic Factors.—Fright, worry, mental d
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