. The diseases of infancy and childhood. e. At this time even without complications it may touch 104° or105° F. The duration of the fever in cases running the usual course iafour or five days. Accompanying the fever there may be anorexia, rest-lessness, loss of sleep, slight indigestion, and other symptoms of a generalindisposition. Both the local and the general symptoms are sometimes more may depend upon the susceptibility of the child, even though thelymph is pure and the vaccination properly done. The original vesiclemay be much larger than usual, and small secondary vesicles m
. The diseases of infancy and childhood. e. At this time even without complications it may touch 104° or105° F. The duration of the fever in cases running the usual course iafour or five days. Accompanying the fever there may be anorexia, rest-lessness, loss of sleep, slight indigestion, and other symptoms of a generalindisposition. Both the local and the general symptoms are sometimes more may depend upon the susceptibility of the child, even though thelymph is pure and the vaccination properly done. The original vesiclemay be much larger than usual, and small secondary vesicles may formin the neighborhood. In very rare instances a generalized eruption oftrue vaccine vesicles occurs with fever and other general symptoms of cor-responding severity (Fig. 170). Single vesicles may be produced on dis-tant parts of the body as a result of auto-inoculation, usually by scratch-ing. When eczema of the face is present, inoculation is not infrequentlycarried thither. Most of the very sore arms and legs, however, are due. Fig. 170. — Generalized old. Boy eight 1002 THE SPECIFIC INFECTIOUS DISEASES to infection from pyogenic bacteria accidentally introduced at the timeof vaccination but more often subsequently. In the milder cases theswelling and other evidences of local inflammation are more marked thanin a normal vaccination; a drop or two of pus forms beneath the crust,and when the latter comes away an excavation is left which heals in twoor three weeks. Or, the inflammation may extend more deeply into theconnective tissue, to be followed by more extensive suppuration or slough-ing, leaving an ugly ulcer an inch or more in diameter which slowly fillsby granulation in from five to eight weeks. Sometimes the period ofincubation is unduly prolonged, so that the vesicle does not form untilthe twelfth or fourteenth day, although its subsequent course may bequite normal. In other cases the incubation is very much shorter thanusual, and the vesicle m
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