Manual of pathological anatomy . normally, be about one-third or one-fourth the whole diameter, is much encroached onand even obstructed by this accumulation of epithelium ; from thesame cause the tube becomes dilated, and hence the bulk of theorgan is increased. Cylinders of fibrine, or hyaline matter, alsoare present in some of the tubes, but not in the great majority,and doubtless aid in increasing the obstruction. The base-ment membrane of the tube, in some cases, is natural, insome, is decidedly atrophied, and scarcely can be detected. Acondition of the epithelium is sometimes observed wh
Manual of pathological anatomy . normally, be about one-third or one-fourth the whole diameter, is much encroached onand even obstructed by this accumulation of epithelium ; from thesame cause the tube becomes dilated, and hence the bulk of theorgan is increased. Cylinders of fibrine, or hyaline matter, alsoare present in some of the tubes, but not in the great majority,and doubtless aid in increasing the obstruction. The base-ment membrane of the tube, in some cases, is natural, insome, is decidedly atrophied, and scarcely can be detected. Acondition of the epithelium is sometimes observed which isextremely significant, we think, of the nature of the morbid pro- MORBUS BRIGHTII. 6S3 cess; it is noticed by Dr. Johnson as peculiar to that form ofdisease which he denominates non-desquamative nephritis. Theepithelium in this does not accumulate and block up the tubes,but appears as a coarsely granular opaque stratum, of the naturalwidth, resting on the basement membrane. Fig. 158. x: ^ ^ ^^, ... A. :!~l^^^(?^ iQuX^^^^kg. A, Tube containing an homogeneous cast, which projects from its broken , Malpighian body, the capsule is filled with oily matter. Besides the swollen and opaque epithelium, cells are sometimesseen which are regarded as indicating proliferation of this structureand have led to this process being described as a renal catarrh : that is to say, detached, spheroidal masses like epithelium, lyingin the middle of the tubes. Where there is no epithelium on thewall of the tube they appear to have been formed out of it, thoughnot of necessity indicating actual cell-proliferation. But moregenerally the adventitious cells are simple exudation- or pus-corpuscles. The Malpighian tufts are more opaque than natural, the capillariesbeing obscured by some material contained in the capsule whichis probably exudative, but which some pathologists derive from thevery delicate epithelium lining the capsule. In some cases thisis so abundant, and so mixed with oily matter
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Keywords: ., bookcentury1800, bookdecade1870, booksubjectanatomy, booksubjectp
