. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 738 ADVENTURES IN RADIOISOTOPE RESEARCH end and the mean value of the specific activity of the tissue inorganic P during the experiment becomes very appreciable. That the fixing of the rat on to the table all through the experiment does not necessarily interfere with the normal circulation, is seen from the following activity ratios: Percentage ratio of the specific activity of the nucleic acid P to that of the inorganic sarcoma P Percentage ratio of the specific activity of the nucleic acid P to that of the inorganic p
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 738 ADVENTURES IN RADIOISOTOPE RESEARCH end and the mean value of the specific activity of the tissue inorganic P during the experiment becomes very appreciable. That the fixing of the rat on to the table all through the experiment does not necessarily interfere with the normal circulation, is seen from the following activity ratios: Percentage ratio of the specific activity of the nucleic acid P to that of the inorganic sarcoma P Percentage ratio of the specific activity of the nucleic acid P to that of the inorganic plasma P Control Fixed to table. In this case the muscles of the rat presumably relaxed. That the effect of fixing can obstruct the circulation to a high degree, is seen from the following figures: Fixed to tab'.e II In our later experiments, in which the animal was irradiated all through the experiment, we placed the rat in a beaker coated with black paper. The X-ray dose administered was controlled by placing a micro-ionising chamber on the sarcoma. In these experiments no appre- ciable difference was found between the results obtained either when the irradiation took place only before the injection or when it took place all through the experiment; as seen in Table 4. Table 4. Irradiation of Rats in Glass Beaker With a Total Dose of 1000 r Control Irradiated uefore injection only Irradiated A] through tlie experiment Specific activity of desoxyribosenucleic acid P, expressed in percentage of the specific activi- tv of sarcoma inoreranic P 1 1 Specific activity of desoxyribosenucleic acid P, expressed in percentage of the specific activi- ty of plasma inorganic P Desoxyribosenucleic Acid Formation in Benzpyrene Sarcomata In a few cases we determined the rate of renewal of desoxyribosenucleic acid in sarcomata obtained by grafting tumour tissue produced by treatment of rats with benzpyrene. The results obtained
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