. The elements of pathological histology with special reference to practical methods . On entering the skin or mucous membrane,the poison tirst sets up a local affection [primary si/philis] in the formof the so-called initial sclerosis [hard or Hunterian chancre]; butlater it makes its way into the circulation, whereupon generalsymptoms ensue in the form of affections of the lymphatic glands,skin, and mucous membranes {secondary syphilis), and still laterdiseased conditions of the internal organs, bones, and blood-vessels{tertiary syphilis). All these affections have the character of inflammat
. The elements of pathological histology with special reference to practical methods . On entering the skin or mucous membrane,the poison tirst sets up a local affection [primary si/philis] in the formof the so-called initial sclerosis [hard or Hunterian chancre]; butlater it makes its way into the circulation, whereupon generalsymptoms ensue in the form of affections of the lymphatic glands,skin, and mucous membranes {secondary syphilis), and still laterdiseased conditions of the internal organs, bones, and blood-vessels{tertiary syphilis). All these affections have the character of inflammations, mostlycircumscribed, resulting in the majority of cases in the formation BACILLUS SYPHILIS 139 of a round-celled tissue, which subsequently either atrophies againor else breaks down. The atrophy and breaking down always beginin the centre of the nodule of new tissue and progress towardsthe circumference. In the former the round-celled tissue maychange first into a cicatricial tissue, whereas the breaking downtakes the form either of caseation or of suppuration and PlG. C4.—Gumma in the Pfriosteum of the Clavicle. x 240.(Haimatoxjlin and eosin.) A, Caseous portion; B, Connective tissue;6, Vascular granulation tissue ; «, Caseated blood-vessel. • The most significant form of syphilitic affection, from a histo-logical point of view, is the syphilitic gumma or sypliiloma whichbelongs to the tertiary period. So long as it is small and young,indeed, this also consists merely of a granulation tissue; but if, as itbecomes larger, caseation occur in the central parts so that one ormore caseous foci are thus formed (Fig. 173, c), the syphiliticgranulation tissue immediately surrounding the latter changes intospindle-celled and cicatricial tissue. Hence three distinct zones canusually be made out in such preparations (Fig. 64): a caseouscentre {A), immediately outside this a zone of spindle-celled orconnective tissue {B), and still further out the granulation tissu
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Keywords: ., bookcentury1800, bookdecade1890, booksubjectpatholo, bookyear1895
