. The endocrine organs; an introduction to the study of internal secretion . andsin animals; nevertheless,castration is followed byits hypertrophy. There isno evidence that any kindof active autacoid substanceis produced by the corticalcells, and it is probable thattheir function is associatedwith the building up ofmetabolic products whichare to find employment inother parts of the organism. STRUCTURE OF THEMEDULLA The medulla is composedof cells which have a differentform and structural appear-ance from those of the cor-tex. They are arranged inwhat appear in section likeirregular anastomosin
. The endocrine organs; an introduction to the study of internal secretion . andsin animals; nevertheless,castration is followed byits hypertrophy. There isno evidence that any kindof active autacoid substanceis produced by the corticalcells, and it is probable thattheir function is associatedwith the building up ofmetabolic products whichare to find employment inother parts of the organism. STRUCTURE OF THEMEDULLA The medulla is composedof cells which have a differentform and structural appear-ance from those of the cor-tex. They are arranged inwhat appear in section likeirregular anastomosing columns with large blood-spaces between. But inpoint of fact the medulla is better described as a solid cell-mass permeatedby sinus-like blood-vessels (fig. 34) with the cells compactly arrangedbetween and around them. The cells of the medulla are irregularlypolygonal in form, but where they abut on the sinuses they often assumea more columnar aspect. There can be little doubt that the materials theysecrete find their way directly into the blood within the FIG. 34.—Section of suprarenal at thin part of 150 diameters. In this section as well asin that shown in fig. 32 the cells of the medullaare stained brown with bichromate of contrast strongly with the cells of the zonareticularis of the cortex. The blood-sinuses of themedulla are seen to be continuous with those of thezona reticularis. Vessels and Nerves of the Suprarenals 55 The cell-protoplasm contains granules which vary in size and amount indifferent cells (Carlier). Some of these granules are stained brown withchromic acid and its salts (adrenalin or chromaphil reaction), and this givesa yellowish-brown colour to the medulla when the suprarenals are fixed inany solution containing these salts. Occasionally the colouration is morediffuse. A similar reaction is sometimes given by the blood and lymph inthe vessels of the medulla in sections of the organ. Besides the chroma
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