. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 602 ADVEJJiTURES IN JIADIOISOTOPE RESEARCH of other experiments by Eheenstein, in which the red corpuscles were labelled in animals with tumours but not in healthy animals, shows that this holds good. The incorporation of the i^C into the erythrocytes is increased fourfold in this case. The mice are able to compensate the curtailment of the life-time of red corpuscles in a quantitative manner by means of increased bone-marrow and spleen function. The cancer patient also usually shows a similar compensation. Mostly, of c
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. 602 ADVEJJiTURES IN JIADIOISOTOPE RESEARCH of other experiments by Eheenstein, in which the red corpuscles were labelled in animals with tumours but not in healthy animals, shows that this holds good. The incorporation of the i^C into the erythrocytes is increased fourfold in this case. The mice are able to compensate the curtailment of the life-time of red corpuscles in a quantitative manner by means of increased bone-marrow and spleen function. The cancer patient also usually shows a similar compensation. Mostly, of course, this is an incomplete compensation. We shall return to this question later. o Concer • Control. Fig. 4. Life-time of red corpuscles labelled in a mouse with carcinoma and in a normal mouse. Figure 4 also shows that a portion of the erythrocytes formed in the animal having carcinoma decays rapidly, from which we may conclude that, apart from the extracorpuscular action to which the red corpuscles are exposed in the tumourous animal, abnormal erythrocytes are also formed to some extent in such an animal. The extracorpuscular damage to the erythrocytes must clearly be attributed primarily to a plasma factor or to activation of the reticulo- endothelial system. Haemolysing substances have often been observed to exist in tumours. It has also been found^^*^ that the volume of the individual erythrocyte undergoes an increase due to the action of the plasma of a cancer patient; a volume increase initiates haemolysis. A range of enzymes are present in enhanced concentration in the plasma of a cancerous organism. Warburg and Christian^^^' '^^' ^3) and others observed a marked enhancement of the aldolase content in plasma when large tumours existed. One in four of the cancer patients studied, was. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not per
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