. Manual of antenatal pathology and hygiene : the foetus. not arranged in rows, and nobone formation takes place. The nose shows flattening, and at thebase of the cranium the formation of the os tribasilare takes place(premature ossification of the bones of the base, namely, pre-sphenoid,basi-sphenoid, and basi-occiput). At the present time the cause of the dystrophy which has beendescribed above is unknown. It may be guessed that the conditionswhich produce rickets in postnatal life are active in a modified formor in a ditfereut degree here, and tliat they arrest the formation of bonefrom car
. Manual of antenatal pathology and hygiene : the foetus. not arranged in rows, and nobone formation takes place. The nose shows flattening, and at thebase of the cranium the formation of the os tribasilare takes place(premature ossification of the bones of the base, namely, pre-sphenoid,basi-sphenoid, and basi-occiput). At the present time the cause of the dystrophy which has beendescribed above is unknown. It may be guessed that the conditionswhich produce rickets in postnatal life are active in a modified formor in a ditfereut degree here, and tliat they arrest the formation of bonefrom cartilage, while they allow the proliferation of the cartilage itself. FCETAL BONE DISEASE 347 FcEtal Bone Disease (Type D). Under the heading of Type D, I group most of the recorded casesof achondroplasia and chondrodystrophia fretahs hypoplastica. Thisdisease does not prove incompatible with postnatal life; consequentlythere are several well-recorded instances of adult achondroplasia, asit is often called. I have, however, to deal here with the malady as. Fig. 50.—Villas case of ftetal bone disease. it is met with in antenatal life. A complete and concise account ofthe disease, both as it occurs in adult and in foetal life, is given byJohn Thomson in Greens jEncydojMdia Medica, vol. i., p. 55, external appearances are very characteristic, and most of therecorded cases bear a very striking resemblance to each other. Inorder to bring out this resemblance, the reader may compare togetherthe cases of E. H. Sonntag {Dissert., Heidelberg, 1844), N. F. Winkler{Arch. f. Gijnach, ii. 101, 1871), A. Fischer {ibid., vii. 45, 1875), 348 AXTKXATAI, IATIIOLOCIV AND HYGIENE J. B. Borntraeger (Dissert., Kijnigsberg, 1877), J. Storp {Dissert.,Kiinigsberg, 1887), A. liiskamp (Dissert., Marbiirg, 1874), F. Hoess(iJissci-t., :\Iaibiiig, 1876), 1!. Ihimpe (, Marburg, 1882), {Diiiscrt., Halle, 1881), A. St-lmeider (Dissert., Berlin, 1892),F. Villa (Ann. cli vstet. e gine
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