Diffuse large B-cell lymphoma, light micrograph. Diffuse large B-cell lymphoma is the most common type of lymphoma and accounts for about 35% of all c

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Diffuse large B-cell lymphoma, light micrograph. Diffuse large B-cell lymphoma is the most common type of lymphoma and accounts for about 35% of all cases of non-Hodgkin lymphoma. It is an aggressive malignancy and presents with rapidly enlarging lymph nodes or tumor masses at extranodal sites. There is diffuse proliferation of large to medium-sized lymphoid cells which can be classified into centroblasts and immunoblasts. Some cases have markedly pleomorphic anaplastic cells. This image shows diffuse large B-cell lymphoma involving the large intestine. The lymphoma cells infiltrate diffusely in between intestinal crypts and distort the native architecture.

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