. A practical treatise on diseases of the skin, for the use of students and practitioners . ptible to it. A large list of other depressing agencies arenamed as effective in its production; such as certain poisons(arsenic?); pyaemia; carcinoma; pulmonary inflammations (in-cluding phthisis); septicaemia; hemorrhages; traumatism; andmalaria. Inasmuch as no one of these causes can he cited ascertainly effective in all cases, it can merely be said that anyinfluence sufficient to induce inflammation of a sensory nerve orits ganglion may he followed by the objective signs of the dis-ease. Pathology.—
. A practical treatise on diseases of the skin, for the use of students and practitioners . ptible to it. A large list of other depressing agencies arenamed as effective in its production; such as certain poisons(arsenic?); pyaemia; carcinoma; pulmonary inflammations (in-cluding phthisis); septicaemia; hemorrhages; traumatism; andmalaria. Inasmuch as no one of these causes can he cited ascertainly effective in all cases, it can merely be said that anyinfluence sufficient to induce inflammation of a sensory nerve orits ganglion may he followed by the objective signs of the dis-ease. Pathology.—The researches of Barensprung, Raver, Wagner,Charcot, Kaposi, and others have demonstrated with sufficientclearness that in zoster there is always, at some point in thecorresponding nervous tract (cerebral or spinal centres, ganglia,or the nerves themselves), pathological changes. These are:enlargements, hemorrhagic effusion, separation, softening, ordestruction of the nervous bundles, witli hyperemia, infiltra-tion and multiplication of the elements which surround thelatter. Pig. -f J Longitudinal section of the third spinal ganglion of the light lumbar region from a case oflnmbo-ingninal zosir-r. «.. ganglion, the black points correspond with pigmented ganglioncells, the dark linfs to engorged vessel- ; «.,.>■.,!.,. fatty tis<uv surrounding (he ganglion : 6,6,nerve filament divided longitudinally at the points of entrance and exit, at c,c, divided per-pendicularly. (Alter Kaposi.) According to Biesiadecki and Haight the cutaneous lesionsoriginate in the deeper portions of the rete, precisely as in othervesicular diseases. The exudate from the hypersemic corium,especially its papillary layer, presses upward into the rete, theepithelia of which are thus separated and vertically elongated. HERPES ZOSTER. 183 The serous exudation finally reaches a point where the hornylajer is forcibly raised from its bed to form the roof of the vesi-cle. The mechanical destructi
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