Physiology and biochemistry in modern medicine . , until about ten stimuli have been applied, afterwhich for some considerable time the same height of contraction followseach stimulus. If each contraction is recorded, it will be seen that thefirst few contractions give a staircase effect; that is, if a horizontal line isdrawn from the top of each contraction to the next one, the effect of a 178 THE CIRCULATION OF THE BLOOD staircase with gradually diminishing steps will be produced. If we repeatthis observation with cardiac muscle, we shall find that the staircasephenomenon or treppe, as it is
Physiology and biochemistry in modern medicine . , until about ten stimuli have been applied, afterwhich for some considerable time the same height of contraction followseach stimulus. If each contraction is recorded, it will be seen that thefirst few contractions give a staircase effect; that is, if a horizontal line isdrawn from the top of each contraction to the next one, the effect of a 178 THE CIRCULATION OF THE BLOOD staircase with gradually diminishing steps will be produced. If we repeatthis observation with cardiac muscle, we shall find that the staircasephenomenon or treppe, as it is called, is very pronounced; and moreover,in obedience to the all or nothing principle, the treppe is obtained incardiac muscle whatever may be the relative strengths of the stimuliapplied to the heart, provided always that all of them are effective;whereas in the case of skeletal muscle it can be demonstrated only pro-vided the stimuli are of equal strength (Fig. 46). 3. If an effective stimulus is applied to a skeletal muscle while in process. Skeletal muscle
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