. Calcified tissues; proceedings. Bone; Collagen; Calcification. L. F. Belanger, T. Semba, S. Tolnai, D. H. Copp, L. Krook, C. Gries The result should be a progressive loss of bone manifested by an enlargement of the osteonic canal and a gradual loss of bone substance. Alpharadiographs of demineralized sections of normal bone have revealed that the areas where osteolysis is occurring are characterized by the presence of enlarged. Fig. 5 and oftentimes confluent lacunae surrounded by low-density matrix (Belanger et al., 1963 b). Newly-formed portions of the tissue, at the border of osteonic can
. Calcified tissues; proceedings. Bone; Collagen; Calcification. L. F. Belanger, T. Semba, S. Tolnai, D. H. Copp, L. Krook, C. Gries The result should be a progressive loss of bone manifested by an enlargement of the osteonic canal and a gradual loss of bone substance. Alpharadiographs of demineralized sections of normal bone have revealed that the areas where osteolysis is occurring are characterized by the presence of enlarged. Fig. 5 and oftentimes confluent lacunae surrounded by low-density matrix (Belanger et al., 1963 b). Newly-formed portions of the tissue, at the border of osteonic canals consist of denser matrix containing small lacunae (Belanger et al., 1963 b). The lower- density matrix of the osteolytic sites stains more intensely with the periodic acid- Schiff and exhibits toluidine blue and azur metachromasia, indicative of a concentra- tion of mucopolysaccharides in these areas (Belanger et al., 1963 b). In the present series, the periodontal bone (lamina dura) was still fairly compact after 4 weeks (Fig. 3). The canals were small but there was already a considerable Intensification of osteolysis. After 7 weeks (Fig. 4), the areas of osteolysis were more extensive and character- ized by lower density of matrix corresponding to more widespread staining. After 12 weeks (Fig. 5), the canalicular arrangement of the lamina dura had in great part disappeared and the newly-formed bone was of the trabecular type. The central portion of the trabeculae showed the characteristic manifestations of osteo- lysis. At this stage consequently, bone formationhad regressed to a more primitive form, but this younger type of bone could still be considered as normal bone. At this stage also, some less dedifferentiated areas, showed the disappearance of the Schiff positive areas characteristic of osteolytic resorption. Numerous, irregular cementing lines separated the areas of new growth. The newly-formed bone con- tained only osteocytes of small size and
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