Modern surgery, general and operative . yenter in large numbers or are peculiarly virulent, or if resistance is low they inducechronic inflammation, granulation tissue forms, and the cells of the focus oftenhave the characteristic arrangement described above. The bacilli are notpyogenic and suppuration means secondary infection. If mixed infection of anyconsiderable area occurs, the patient is apt to develop fever and to perish from ex-haustion, amyloid disease, dissemination, or a terminal infection. In rare casesthe tuberculous area is destroyed and cure is brought about. A tuberculousfocus


Modern surgery, general and operative . yenter in large numbers or are peculiarly virulent, or if resistance is low they inducechronic inflammation, granulation tissue forms, and the cells of the focus oftenhave the characteristic arrangement described above. The bacilli are notpyogenic and suppuration means secondary infection. If mixed infection of anyconsiderable area occurs, the patient is apt to develop fever and to perish from ex-haustion, amyloid disease, dissemination, or a terminal infection. In rare casesthe tuberculous area is destroyed and cure is brought about. A tuberculousfocus tends strongly to degenerative changes because of the local anemia andthe presence of bacilli. If numerous active bacilli are present caseation takesplace. This is coagulation necrosis due to the action of bacteria upon a non-vas-cular area. It starts at the center of a tuberculous focus and spreads towardthe periphery and finally forms masses like cheese. When caseated materialis mixed with serum tuberculous pus is formed. ,.„,.mm. Fig. 104.—Synovialmembrane, showing giant-cells (Bowlby). The Incidence of Tuberculosis 237 A caseated focus may be surrounded or encapsulated by fibrous this happens the tuberculous process may remain latent for monthsor years, perhaps awakening into activity as the result of a traumatisn orlowered general resistance. A caseated focus may be cured by growth of fibroustissue which replaces the tuberculous focus. This is cure by sclerosis. Acaseated area may calcify. Even when tuberculous pus forms, encapsulationmay occur, the fluid being absorbed, and the remains being surrounded byfibrous tissue. Whenever tubercle bacilli consume all available food they die orremain latent. If they die the granulations are converted into fibrous tissue andthe part is healed. If they remain latent they may at any time become againactive. Infiltrated tubercle is due to the running together of many minuteinfective foci, or to widespread infiltration wi


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