Interstate medical journal . Theeffect is most marked upon the respiration. As seen by Chart 1,the respiration ceased while the heart was still beating. Atropineantagonized the effect upon the respiration so that it was onlyafter very large doses that death would result. (See Chart 2.)Salant and Livingston,9 in a series of experiments upon isolatedfrogs hearts, came to the conclusion that the drug probably affectedthe muscular substance of the heart. It was noted that, when atropine was previously injected intra-venously until the vagi no longer responded to electric stimula- 972 INTERSTATE ME
Interstate medical journal . Theeffect is most marked upon the respiration. As seen by Chart 1,the respiration ceased while the heart was still beating. Atropineantagonized the effect upon the respiration so that it was onlyafter very large doses that death would result. (See Chart 2.)Salant and Livingston,9 in a series of experiments upon isolatedfrogs hearts, came to the conclusion that the drug probably affectedthe muscular substance of the heart. It was noted that, when atropine was previously injected intra-venously until the vagi no longer responded to electric stimula- 972 INTERSTATE MEDICAL JOURNAL tion, .01 mil of oil of chenopodium administered in a like mannercontinued to produce a fall in blood pressure with each differed inasmuch as when the oil was injected alone the pres-sure did not fall with the second injection. This shows that thefall in pressure is not due to a slowing of the heart from vagusstimulation. It is probably due to depression of the vasomotorcenter and heart The convulsions which occurred several hours after the adminis-tration of toxic doses of oil of chenopodium are of interest. Theywere always preceded by coma and resembled struggling ratherthan a convulsion due to a direct convulsive effect. This strugglingwas often accompanied by barking. The noise was so great thatin several instances chloroform or morphine had to be causes are suggested: (1) That it may be due to the ap-proaching asphyxia, caused by the depression of the respiratorycenter. (2) Due to an anemia of the nervous centers, caused bythe lowering of blood pressure. (3) That it may be due to a neuritictoxemia. I am inclined to believe from the postmortem findingsthat the last theory is correct. Zeigler: A Study of Oil of Chenapodium 973 In view of the fact that in the various outlines of treatment ofhookworm disease the dose of oil of chenopodium is given in bothdrops and minims, it may be well to call the attention of the pro
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