. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. 90 M. R. Pollock immunological comparison with 5/B penicillinase is possible. Fig. 2 shows how a partially absorbed anti-569 antibody pre- paration neutralizes the 5/B enzyme and a preparation of 5 penicillinase (obtained from a culture supernatant fluid concentrate) to give identical neutralization slopes. The 5/P enzyme is likewise indistinguishable from 5 and 5/B; whereas the 569 penicillinase gives a quite different slope. Results obtained (in a diff*erent experi
. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. 90 M. R. Pollock immunological comparison with 5/B penicillinase is possible. Fig. 2 shows how a partially absorbed anti-569 antibody pre- paration neutralizes the 5/B enzyme and a preparation of 5 penicillinase (obtained from a culture supernatant fluid concentrate) to give identical neutralization slopes. The 5/P enzyme is likewise indistinguishable from 5 and 5/B; whereas the 569 penicillinase gives a quite different slope. Results obtained (in a diff*erent experiment) with culture supernatant 496 749. '04 '06 ml. antiserum Fig. 2. Neutralization of different penicillinases by partially-absorbed anti-penicillinase serum. fluids from penicillinase-producing strains of B. suhtilis and B. megaterium show no neutralization whatever and indicate that their enzymes are far less closely related to 569 penicil- linase than those of the 5 group. This immunological test can therefore be regarded as a very sensitive indication of probable identity. It appears reasonable to conclude that within each family of strains the change in rates of increase of penicillinase activity—whether occurring by enzyme induction or by mutation—reflects a purely quanti- tative alteration in the rates of formation of the same Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
Size: 1812px × 1379px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookcollectionb, bookpublisherbostonlittlebrown
