. Advanced lessons in practical physiology for students of medicine. Physiology. 222 ADVANCED LESSONS IN PRACTICAL PHYSIOLOGY The injection of so large a quantity of solvent is prone to produce a material rise in the blood-pressure, thereby increasing the filtration pressure. For this reason the diuretic effect of sodium chlorid is fre- quently referred to this cause, in combination with hydremia and osmotic changes, and not to a direct stimulating action upon the renal cells. 5. Effect of Changes in Blood-pressure.—When an active secretion has been produced, stimulate the vagus nerve, thereby
. Advanced lessons in practical physiology for students of medicine. Physiology. 222 ADVANCED LESSONS IN PRACTICAL PHYSIOLOGY The injection of so large a quantity of solvent is prone to produce a material rise in the blood-pressure, thereby increasing the filtration pressure. For this reason the diuretic effect of sodium chlorid is fre- quently referred to this cause, in combination with hydremia and osmotic changes, and not to a direct stimulating action upon the renal cells. 5. Effect of Changes in Blood-pressure.—When an active secretion has been produced, stimulate the vagus nerve, thereby evoking a material reduction in the general blood-pressure. While the secretion of urine is then greatly lessened, note that the flow does not return to normal until a considerable time after the cessation of the stimulation. This fact tends to show that while the blood-pressure is an important factor in the production of urine, the secreting cells are not dominated by pressure alone. Dilute a 1 : 1000 solution of adrenahn sufficiently to cause a moder- ate rise in blood-pressure (2 of the solution to 20 of sahne). Register the flow of urine. Inject a small quantity of the aforesaid. Fig. 123.—Effect of Stimulation of the Vagus Nerve Upon the Secretion of Urine. solution of adrenalin in the external jugular vein. Note that the flow of urine is greatly lessened thereby in spite of the high blood-pressure. This discrepancy is easilj'- explained, because the adrenalin constricts the blood-vessels of the kidney, and gives rise to a lessened vascularity of this organ and lessened secretory power of its cells. 6. Rapidity of Elimination.—Prepare a saturated solution of indigo- carmin. Inject 5 of this solution in the external jugular vein, not^ ing the moment of the injection. Again determine the time when this pigment appears in the urine. Kill the animal by an overdose of ether. 7. Dissection of the Region of the Kidney.—Identify the suprarenal bodies on eac
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