Induced cell-reproduction and . occupied a long time. The constituents of theextracts of the body are well known. It may beremembered that the active principle in the extracts isevidently thermostable, and remains in solution aftermost of the proteins have been precipitated by tried certain salts, and other substances, and wehave also tried urea, and at last hreatin (C4H9N302)was found to be a substance which will induce divisionsin lymphocytes (fig. 106) and leucocytes (fig. 107).Kreatinin (C4H7NsO) is not effective in the experi-mental ten minutes; but xanthin (C5H4N402) is
Induced cell-reproduction and . occupied a long time. The constituents of theextracts of the body are well known. It may beremembered that the active principle in the extracts isevidently thermostable, and remains in solution aftermost of the proteins have been precipitated by tried certain salts, and other substances, and wehave also tried urea, and at last hreatin (C4H9N302)was found to be a substance which will induce divisionsin lymphocytes (fig. 106) and leucocytes (fig. 107).Kreatinin (C4H7NsO) is not effective in the experi-mental ten minutes; but xanthin (C5H4N402) is ifits action is augmented by atropine. The following table gives the strengths of kreatinand xanthin required to be contained in the 10 cc. ofjelly in order to induce divisions in lymphocytes in theexperimental ten minutes, no atropine being employed,but the jellies contained 1 cc. (10 units) of alkalisolution. Kreatin. gramme . . No mitosis seen. ... Early mitosis. . . Well-advanced divisions. KREATIN AND XANTHIN 317. Fig. 106.—Mitosis induced in a lymphocyte by kreatin. No stain or extract.
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