. Diseases of bones and joints . sbeen observed. If this observation is correct, thecondition consists not only in a lack of formationof new bone, but also in a destruction of bone al-ready formed. The Haversian canals may bewidened to form large open spaces. The abnormal bone formation is probably due todisease of the marrow and of the deep layer of theperiosteum. In Lovett and Nichols case the mar-row near the epiphyseal line and in the cortex waschanged to an edematous, myxomatous, con-nective tissue. Do ring observed a fibrous degen- Marroweration of the marrow in his case, and inflamma-to
. Diseases of bones and joints . sbeen observed. If this observation is correct, thecondition consists not only in a lack of formationof new bone, but also in a destruction of bone al-ready formed. The Haversian canals may bewidened to form large open spaces. The abnormal bone formation is probably due todisease of the marrow and of the deep layer of theperiosteum. In Lovett and Nichols case the mar-row near the epiphyseal line and in the cortex waschanged to an edematous, myxomatous, con-nective tissue. Do ring observed a fibrous degen- Marroweration of the marrow in his case, and inflamma-tory changes in the neighbourhood of the necroticbone. the ChiefFactor 1 In Biggs case the disease appeared at the age of 20, and ceasedat 30. 200 DISEASES OF BONES AND JOINTS SYMPTOMATOLOGY. The chief clinical manifestations of the diseaseare the abnormal friability of the bones and themultiple fractures. The fractures may occur inutero or after birth. Callus can be felt at the loca-tion of the older ones. The skull is wont to be. Fig. 84. Osteopsathyrosis Idiopathica. Skiagram of lower extremities (Osgood). large, and the fontanelles remain open until verylate. Teething is also much retarded. Accordingto Nathan the skin and subcutaneous tissues arethickened, giving an appearance similar to that ofchondrodystrophia. The diagnosis is made on the multiple fractures, DISEASES OF BONES AND JOINTS 201 occurring usually in a new-born baby or in a youngchild. The only known treatment is to keep the child as carefully as possible, with the idea of prevent-ing further fractures. BIBLIOGRAPHY. Schwartz and Bars, American Journal of Diseases ofChildren, 1913, V, 131. Lewy, J., Deutsche mediz. JVochenschrift, 1912, No. 40,1875. Biggs, Univ. of Penn. Med. Bull., 1903, XV, 488. Lovett and Nichols, British Med. Jour., 1906, II, 915. Nathan, P. W., Amer. Jour. Med. Sciences, 1905,CXXIX, 1. Doring, Deutsche med. Wochensch., 1904, XXX, 1786. OSTEOMALACIA. Osteomalacia, means a softness of bone. I
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