. The thyroid gland in health and disease. ty of colloid. Gland invaded by fibroblasts. Theparathyroid is the darker, oval area (indicated by the white pointer) embedded inthe periphery of the thyroid. It is almost completely destroyed by hsemorrhagesinto its substance. X 90. tetany arise. The young rats, during the three to four daysthey were allowed to live, showed no nervous symptoms of anykind so far as I could detect. Their intestines were probablysterile up to the time of their death and the toxic irritantnecessary for the production of the symptoms was, therefore,lacking. Had they been
. The thyroid gland in health and disease. ty of colloid. Gland invaded by fibroblasts. Theparathyroid is the darker, oval area (indicated by the white pointer) embedded inthe periphery of the thyroid. It is almost completely destroyed by hsemorrhagesinto its substance. X 90. tetany arise. The young rats, during the three to four daysthey were allowed to live, showed no nervous symptoms of anykind so far as I could detect. Their intestines were probablysterile up to the time of their death and the toxic irritantnecessary for the production of the symptoms was, therefore,lacking. Had they been allowed to live they would certainly 154 PARATHYROID DISEASE AND TETANY have shown tetanoid symptoms sooner or later, for such symptomsare known to be associated with similar parathyroid lesions inchildren. Escherich found hsemorrhagic lesions of these glands,identical with those I have produced experimentally in rats, inthirty-nine out of an unselected series of eighty-nine infants inhis clinic showing nervous symptoms. He noted that the. Fig. 68.—Section of normal thyroid and parathyroid gland from a 4-day-oldrat. From same case as fig. 49, which shows the normal isthmus. X 180. severity of the tetanoid symptoms was directly proportional tothe severity of the pathological changes in the attributed the haemorrhages into the parathyroids to injuryat birth, but in the light of my experimental findings in ratsthese haemorrhagic lesions are to be attributed not to traumaat birth but to the action on the foetal glands of the highlyvirulent products of anaerobic organisms in the maternal findings appear to me to indicate that the factors in the PARATHYROID DISEASE 155 origin of tetany are (1) a toxic substance which wholly, or moreusually partially, destroys the parathyroid and which, as a rule,injures the thyroid at the same time, and (2) a toxic irritantwhich by its action on the central nervous system gives rise tothe symptoms. It is very probabl
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