Tumorigenesis. Light micrograph showing proliferation in clusters of lung cells from a rat embryo due to an externally-induced mutation of the tumour

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Tumorigenesis. Light micrograph showing proliferation in clusters of lung cells from a rat embryo due to an externally-induced mutation of the tumour suppressor gene (anti-oncogene) p53. The protein expressed by p53 provides a natural block against the proliferation of cell division that initiates the growth of a cancer (tumorigenesis). Here, the inactivity of mutant p53 is believed to give rise to these circular groups of proliferating cells. The mutation was provoked by placing the lung cells in contact with benzo[a]pyrene, a potent carcinogen (cancer- inducing substance) found in tobacco smoke.

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Size: 3562px × 2480px
Photo credit: © PHILIPPE PLAILLY/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
Model Released: No

Keywords: anti, anti-oncogene, cancer, cancerous, condition, disease, disorder, gene, healthcare, light, malignancy, malignant, medical, medicine, micrograph, mutation, onco-, p53, supressor, tumour, tumourigenesis