. Endocrinology. of theopinion that only the generative part of the testicle has an endo-crine function, the cells being a trophic organ forthe former. Different experiments performed by myself and my co-workers, Wagner, Ottoiv, Bormann and Kropman, during thepast two years have enabled us to throw some light on certainaspects of the problem. In the folloAving I will present a shortaccount of the observations we have communicated in differentplaces; some of them have not been previously published. ?(Viewed in my book Die Iubertatsdriise und ihre 2 SEAT OP ENDOCRINE FUNCTION OF TE
. Endocrinology. of theopinion that only the generative part of the testicle has an endo-crine function, the cells being a trophic organ forthe former. Different experiments performed by myself and my co-workers, Wagner, Ottoiv, Bormann and Kropman, during thepast two years have enabled us to throw some light on certainaspects of the problem. In the folloAving I will present a shortaccount of the observations we have communicated in differentplaces; some of them have not been previously published. ?(Viewed in my book Die Iubertatsdriise und ihre 2 SEAT OP ENDOCRINE FUNCTION OF TESTICLE I. Is a normal internal secretion of the testicle in mammalspossible without fully developed interstitial cells? That this isnot possible is shown by two of our experiments. A. On a rabbit (4) (Prot. No. 4) about a month old oneentire testicle and half of the second were removed. The animalwas observed until the age of 8 months. The penis remainedinfantile. A small testicular fragment was found. That the. Fig. 1. Section througli testicle of a rabbit 6/^ months old, semicastratedat an age of 6 weelcs. The animal had a normal penis. Interstitial cells with alarge area of protoplasm around the nucleus. Seminal tubules in full spermato-genesis (not drawn). Fixation, Helly; Stain, [All figures from prepa-rations of Dr. Wagner, drawn by Miss U Lebbert (except Fig. ,3, drawn by ) with the drawing apparatus of Leitz. Obj. Zeiss D. The scale is givenin Fig. .0. All figures are reduced one-half.] eunuchoidism of this animal Avas not caused by the fact that thequantity of testicular substance was too small, is shown byour numerous experiments on guinea pigs. In these animalsextraordinarily small testicular fragments, representing onlyabout 1 per cent of the weight of two normal testicles, weresufficient for the full development of the somatic sexual charac-ters (5). The eunuchoidism in this experiment must have beencaused by the underdevelopment of the testicula
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