Diffuse large B-cell lymphoma, light micrograph. Diffuse large B-cell lymphoma is the most common type of lymphoma and accounts for about 35% of all c

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Diffuse large B-cell lymphoma, light micrograph. Diffuse large B-cell lymphoma is the most common type of lymphoma and accounts for about 35% of all cases of non-Hodgkin lymphoma. It is an aggressive malignancy and presents with rapidly enlarging lymph nodes or tumor masses at extranodal sites. There is diffuse proliferation of large to medium-sized lymphoid cells which can be classified into centroblasts and immunoblasts. Some cases have markedly pleomorphic anaplastic cells. This photomicrograph shows diffuse large B-cell lymphoma involving the cervix. Normal squamous mucosa can be seen on the left. There is a diffuse lymphoid infiltrate displacing and distorting the endocervical glands.

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Photo credit: © WEBPATHOLOGY/SCIENCE PHOTO LIBRARY / Alamy / Afripics
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