. Colchicine in agriculture, medicine, biology, and chemistry. Colchicine; Colchicine. Pharmacology 187 30000 r .leukocytes (total ) . granulocytes _ _ ^ hours: o 10 20 30 40 50 60 70 80 90 Fig. —Modifications of the leukocyte count of a dog injected mg kg colchicine. (After Dixon and Maiden"') In a later paper,-i j, j^ nRiitioncd tliai after repeated injections ol colcliicine in rabbits, "sections of smears ol the bone-niarroAv . . exhibit proliferation . . : j^lrtitifiil mitotic forms (tni orcasionaUy be obsen'cd" [our it
. Colchicine in agriculture, medicine, biology, and chemistry. Colchicine; Colchicine. Pharmacology 187 30000 r .leukocytes (total ) . granulocytes _ _ ^ hours: o 10 20 30 40 50 60 70 80 90 Fig. —Modifications of the leukocyte count of a dog injected mg kg colchicine. (After Dixon and Maiden"') In a later paper,-i j, j^ nRiitioncd tliai after repeated injections ol colcliicine in rabbits, "sections of smears ol the bone-niarroAv . . exhibit proliferation . . : j^lrtitifiil mitotic forms (tni orcasionaUy be obsen'cd" [our italics].* There can be no doubt toda\ that the sionificance ol these his- tological changes was not grasped. These pui)li( ations on colchicine pharniacologv were widely quoted, and Un 2t) vears text books * ]our. ;?7(1908), p. 7( Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Eigsti, O. J. (Orie Jacob), 1908-; Dustin, Pierre. Ames, Iowa State College Press
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