. The thyroid gland in health and disease. birth, since the offspring of thecontrol rats and of those receiving aerobic cultures were whollyfree from them. The lesions were of a constant character andaffected the internal (those included in the thyroid) (figs. 67-69),as well as the external parathyroids where these were present. The changes consisted in engorgement of the vessels of theglandule and of haemorrhage into it, which destroyed large portionsof its substance (figs. 67, 69), and which, had the animals beenallowed to survive, would have led to their complete or partialfibrosis. While i
. The thyroid gland in health and disease. birth, since the offspring of thecontrol rats and of those receiving aerobic cultures were whollyfree from them. The lesions were of a constant character andaffected the internal (those included in the thyroid) (figs. 67-69),as well as the external parathyroids where these were present. The changes consisted in engorgement of the vessels of theglandule and of haemorrhage into it, which destroyed large portionsof its substance (figs. 67, 69), and which, had the animals beenallowed to survive, would have led to their complete or partialfibrosis. While in all cases of congenital parathyroid disease PARATHYROID DISEASE 153 observed in rats the thyroid gland was also diseased (hyper-plastic) to a greater or lesser extent, it was remarkable that thehaemorrhagic lesions of the parathyroid were constantly observedto be confined within the capsular limits of these glandules. This experiment, while it indicates how the parathyroid glandsmay become diseased, does not indicate how the symptoms of. Fig. 67.—-Thyroid and parathyroid of 3 to 4-day-old rat. Mother fed on fsecalanaerobes during pregnancy. Thyroid is markedly hyperplastic : lobulated appear-ance gone, vesicles rare and empty of colloid. Gland invaded by fibroblasts. Theparathyroid is the darker, oval area (indicated by the white pointer) embedded inthe periphery of the thyroid. It is almost completely destroyed by hsemorrhagesinto its substance. X 90. tetany arise. The young rats, during the three to four daysthey were allowed to live, showed no nervous symptoms of anykind so far as I could detect. Their intestines were probablysterile up to the time of their death and the toxic irritantnecessary for the production of the symptoms was, therefore,lacking. Had they been allowed to live they would certainly 154 PARATHYROID DISEASE AND TETANY have shown tetanoid symptoms sooner or later, for such symptomsare known to be associated with similar parathyroid lesions inchildren. E
Size: 1584px × 1578px
Photo credit: © The Reading Room / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookdecade1910, bookpublishernewyorkwilliamwood
