. The Biochemical journal, 1912. Biochemistry. 224 BIO-CHEMICAL JOURNAL 4. Alteration in Rate of Coronary Flow. Digipuratum has a far more powerful action than the other preparations, the rate of coronary flow sinking from 5 in 60 seconds to 5 in 201 seconds. Digalen comes next with a fall of from 5 in 55 seconds to 5 in 90 seconds. Digitalone produced a fall of from 5 in 42 seconds to 5 in 65 seconds. This gives the following table of percentage diminution in rate of coronary flow: — 2330% 63-6% 54-8% 40-0% The results are shown graphically in Fig. 4. It will be n
. The Biochemical journal, 1912. Biochemistry. 224 BIO-CHEMICAL JOURNAL 4. Alteration in Rate of Coronary Flow. Digipuratum has a far more powerful action than the other preparations, the rate of coronary flow sinking from 5 in 60 seconds to 5 in 201 seconds. Digalen comes next with a fall of from 5 in 55 seconds to 5 in 90 seconds. Digitalone produced a fall of from 5 in 42 seconds to 5 in 65 seconds. This gives the following table of percentage diminution in rate of coronary flow: — 2330% 63-6% 54-8% 40-0% The results are shown graphically in Fig. 4. It will be noticed that Digipuratum produces its maximum effect in 10 minutes, whilst that of Dia-alen is not reached till 45 minutes after the drug was first admitted to the perfusing fluid. Digipuratum Digalen Digitalone ... Tincture of digitalis. Tincture of ^mm Digitalis — Digitalone Digalen Digipuratum Pig. 4. Variation in Rate of Coronary Flow in the Isolated Heart. 5. Variation in Height of Mean Tonus. These results were obtained by measuring the height of the middle point of the curve above the base-line at certain times. It was found that, starting from an average height of 23 mm., Digalen produced an increase in tonus to 28 mm. in 10 minutes, after which followed a gradual. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Biochemical Society (Great Britain); University of Liverpool. Biochemical Dept. London [etc. ] Cambridge University Press
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