. Calcified tissues; proceedings. Bone; Collagen; Calcification. 17 Fig. 2. Schematic illustration of the organization of collagen fractionated from soft and calcified connective- tissues. From left to right are represented the neutral isotonic salt extractable collagen (N) compared to the least calcified bone collagen, the neutral hypertonic salt extracted collagen (NM) from more compact fibers and the denser more calcified bone structures, the fibers extracted in acid medium (A) and the calcified fibrous element, finally, the bulk of the Insoluble fibers (I) and of the 2
. Calcified tissues; proceedings. Bone; Collagen; Calcification. 17 Fig. 2. Schematic illustration of the organization of collagen fractionated from soft and calcified connective- tissues. From left to right are represented the neutral isotonic salt extractable collagen (N) compared to the least calcified bone collagen, the neutral hypertonic salt extracted collagen (NM) from more compact fibers and the denser more calcified bone structures, the fibers extracted in acid medium (A) and the calcified fibrous element, finally, the bulk of the Insoluble fibers (I) and of the most calcified bony structures collagen is synthesized in bone, It appears in the extracellular space as a very loose arrangements of molecules comparable to the N fraction of soft connective tissue. These loose fibers undergo immediate calcification as seen with the electron micro- scope (S. F. Jackson, 1957). They may already have been present inside the osteoblast according to Scott and Glimcher (1963). As they are loose fibers and slightly calcified they contain a large amount of bound water and therefore have a light density. As time passes after the formation of this new bone, the amount of water decreases in the fibers while the deposition of calcium salt Increases. This process can be compared to the maturation of the fibers In soft connective tissue. Their increased organization requires a hypertonic medium for extraction (NM). This condensation process has been demonstrated in vitro by Gross (1958 c). A further evolution of the process of maturation and calcification of the newly formed element would lead to. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original European Symposium on Calcified Tissues; European Bone and Tooth Symposium. Berlin, New York [etc. ] Springer-Verlag [etc. ]
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