The Journal of biological chemistry . ain, which shows that the injected calcium is disposedof in some manner. To find what happens to the injected calcium, three of thetetanic dogs were given a fixed dose of calcium chloride intra-venously, and the urine and feces for 24 hours were analyzed for \ CO £ u 12 oS 10 O-S g •do e 6 Hps. after injection fe c S en oo oo ^ ^ Fig. 1. Calcium and phosphorus in serum following the injection gm. of calcium chloride intravenously in Dog 11, weight kilos. calcium by the methods of McCrudden (14), The previous dayand the day of the experiment the
The Journal of biological chemistry . ain, which shows that the injected calcium is disposedof in some manner. To find what happens to the injected calcium, three of thetetanic dogs were given a fixed dose of calcium chloride intra-venously, and the urine and feces for 24 hours were analyzed for \ CO £ u 12 oS 10 O-S g •do e 6 Hps. after injection fe c S en oo oo ^ ^ Fig. 1. Calcium and phosphorus in serum following the injection gm. of calcium chloride intravenously in Dog 11, weight kilos. calcium by the methods of McCrudden (14), The previous dayand the day of the experiment the dogs were given a calcium-freediet. The colon was rinsed out at the beginning and close ofthe period. The curves for the serum calcium and phosphoruswere determined during this period. Fig. 1 shows the effect of the injection of gm. of CaCl2 onthe serum calcium and phosphorus in one of the dogs. It isseen that 15 minutes after the injection the calcium was decreased rapidly. 24 hours after, the calcium had the same. Harald A. Salvesen 447 value as before the injection; that is, there had disappeared fromthe blood an amount of calcium exactly corresponding to theamount injected. There was also a rise in the phosphates. Thecurves for the other dogs closely resembled this curve. AsTable II shows there was excreted an amount of calcium corre-sponding to the amount injected, but more than nine-tenths wereexcreted in the feces and less than one-tenth in the urine. This rapid disappearance of the injected calcium may explainwhy the calcium treatment reported by previous workers failedto keep the animals alive. Only a few hours after the injectionof a relatively large dose of calcium chloride the blood calciumis down to a level where tetany usually occurs. The experimentsalso show that in parathyroidectomized dogs there is a loweredthreshold for the excretion of calcium through the intestines. TABLE 11. Calcium Excretion in Urine and Feces. June 20 to 21, 1922
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Keywords: ., bookcentury1900, bookdecade1900, booksubjectbiochem, bookyear1905
