. Calcified tissues; proceedings. Bone; Collagen; Calcification. Electro-mechanical Factors Regulating Bone Architecture 85 osteogenesis, while regions of positivlty may be characterized by osteolysis. It was interesting, therefore, to observe the effects on living bone of artificially induced, continuous, direct currents (Bassett et al., 1964). These experiments involved the. Fig. 4. Scheme of possible effects of stress-generated potentials in aiding the ebb and flow of charged molecules and ions about an osteocyte. Note pulse pattern — it is unequally biphasic since deforming force removed b
. Calcified tissues; proceedings. Bone; Collagen; Calcification. Electro-mechanical Factors Regulating Bone Architecture 85 osteogenesis, while regions of positivlty may be characterized by osteolysis. It was interesting, therefore, to observe the effects on living bone of artificially induced, continuous, direct currents (Bassett et al., 1964). These experiments involved the. Fig. 4. Scheme of possible effects of stress-generated potentials in aiding the ebb and flow of charged molecules and ions about an osteocyte. Note pulse pattern — it is unequally biphasic since deforming force removed before signal had decayed implantation of small, active and inactive-control, silicone-coated battery packs in canine thighs, so that two platinum electrodes projected through the lateral mid- femoral cortex into the medullary canal. The active packs delivered currents ranging from to // amps, in vivo. Control specimens developed small masses of new, reactive bone around each inactive electrode where it projected into the marrow space. When 2 to 3 // amps, were flowing, the mass of newly formed bone was increased markedly about the cathode, but not the anode. The larger bone mass near the nega- tive pole seemed to result from an increased cellularity which was most marked at 14 days after operation and which decreased by 21 days. From the pattern of deposition, both at the cathodes and anodes, it was unlikely that the results could be ascribed to an electrophoretic action of the current on precursors of osseous matrix. There was no evidence that an anticipated increase in osteoclastic activity had occurred in the anodal region. In seeking an explanation for this result, it is impor- tant to note that the animals were active during the post-operative period and developed, most probably, significant stress concentrations in the region of both holes in the cortex. Such stress concentrations could result in increased electrical activity which might have overridden the loca
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