The endemic diseases of the southern states . tle meat and largelyof corn and other vegetable foods. Corn is said to have beenintroduced into Spain between 1680 and 1700. Oviedo remainsto this day a hot bed of the disease. Pellagra was, according to Terzagli, known in Italy evenearlier than 1730, isolated cases having been observed in theneighborhood of Sesto Calende. The disease appears to havespread rapidly appearing simultaneously in the districts ofMilan, Brescia, Bergono, and Lodi and soon after in the vicinityof Como, Cremona, Mantna and Paira, toward the end of thecentury extending almo
The endemic diseases of the southern states . tle meat and largelyof corn and other vegetable foods. Corn is said to have beenintroduced into Spain between 1680 and 1700. Oviedo remainsto this day a hot bed of the disease. Pellagra was, according to Terzagli, known in Italy evenearlier than 1730, isolated cases having been observed in theneighborhood of Sesto Calende. The disease appears to havespread rapidly appearing simultaneously in the districts ofMilan, Brescia, Bergono, and Lodi and soon after in the vicinityof Como, Cremona, Mantna and Paira, toward the end of thecentury extending almost entirely throughout Lombardy. Thename Pellagra was given the malady by Prapolli in 1771, and 282 ENDEMIC DISEASES OF THE SOUTHERN STATES probably means rough skin. As the disease invaded newareas in Italy the number of cases in the earlier foci increasedrapidly. In 1784 a pellagra hospital was established in Legnanounder the supervision of the elder Strambio. Marzari in 1810is said to have been the first to infer an etiologic relationship. deitqnxnV.\CCJiCetacartKnaan Fig. 66.—Casals illustration of the cutaneous lesions in pellagra. between the consumption of maize and pellagra. On accountof the early invasion of Italy, of the extensive prevalence ofthe disease in that country and of the attention paid to thescourge by scientists and by the government, Italy may wellbe regarded as the home of the disease. PELLAGRA 283 Our first knowledge of pellagra in France originates withHameau who, in 1829, published his observations of cases since1818 in the vicinity of Teste-de-Buche and in the plain ofArcachon and in the coast region of the Giroude. For the lastquarter of a century there has been little if any pellagra inFrance. Pellagra was first described in Roumania by Caillat in 1854,who states that the disease was unknown there prior to Corpi isolated cases were observed in 1839, but only since1856 has the malady assumed an endemic character. Nicholasand Hambon reporte
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