. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . limb was perfused and the abdominal aorta both experiments good dilatations were obtained from injectingadrenalin into the jugular vein. The sacral, lumbar and lower half of the thoracic cord were destroyed 172 F. A. HARTMAN, L. G. KILBORN AND L, FRASER in two cats. The perfused hind hmb in each case dilated when adrena-Un was injected into the jugular vein (fig. 2). The dose of adrenalinnecessary to do this was larger than is the case in a normal limb, per-haps because of the faulty circulation in the lumbar
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . limb was perfused and the abdominal aorta both experiments good dilatations were obtained from injectingadrenalin into the jugular vein. The sacral, lumbar and lower half of the thoracic cord were destroyed 172 F. A. HARTMAN, L. G. KILBORN AND L, FRASER in two cats. The perfused hind hmb in each case dilated when adrena-Un was injected into the jugular vein (fig. 2). The dose of adrenalinnecessary to do this was larger than is the case in a normal limb, per-haps because of the faulty circulation in the lumbar region caused byclamping the aorta above the bifurcation. We do not find the samedifference after the operation in dogs as in cats, owing no doubt partlyto the great number of anastomoses in a larger animal. These results were confirmed by experiments in which the connec-tion between the central nervous system and the limb under observa-tion was severed, after which no reduction was found in the dilatationcaused by adrenahn. We chose dogs for this operation. The spinal. Fig. 2. Dilatation of a perfused hind limb in a cat (weight kgm.) to 1 cc,1: 10,000 adrenalin injected into the jugular vein after complete destruction ofthe spinal cord downward from the eighth thoracic level. Base of bellows 26mm. X 13 mm. (Reduced one-half.) nerve roots were exposed on one side by removing the laminae and partof the transveise processes, but not the spines. Bleeding from thesinuses was stopped by hot saline packs from time to time. In thefirst experiment both dorsal and ventral roots of the sacral and lumbarregions were cut close to the cord on one side. The limb of that sidewas placed in a plethysmograph and perfused. The aorta and venacava were tied. Injection of cc, 1:20,000 adrenalin into thejugular vein caused a pronounced dilatation of the perfused limb, inspite of the low blood pressure which had resulted from hemorrhage,and succeeding doses of the same strength h^ad a similar
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