. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 410 THE CYTOSKELETON. P LECTIN INTERMEDIATE FILAMENTS MICROTUBULES ACTIN FILAMENTS MYOSIN FILAMENTS PUTATIVE MEMBRANE COMPONENTS Figure 1. Diagram illustrating integration of the cytoskeleton. Plec- tin sidearms on IFs link them to microtubules, myosin II minifilaments. actin filaments, and putative membrane components, thus mechanically connecting various cellular structures. 1996). Though plectin prefers to associate with IFs, it can cross-Hnk cytoskeletal structures in the absence of vimentin. Consequently, plectin may be
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. 410 THE CYTOSKELETON. P LECTIN INTERMEDIATE FILAMENTS MICROTUBULES ACTIN FILAMENTS MYOSIN FILAMENTS PUTATIVE MEMBRANE COMPONENTS Figure 1. Diagram illustrating integration of the cytoskeleton. Plec- tin sidearms on IFs link them to microtubules, myosin II minifilaments. actin filaments, and putative membrane components, thus mechanically connecting various cellular structures. 1996). Though plectin prefers to associate with IFs, it can cross-Hnk cytoskeletal structures in the absence of vimentin. Consequently, plectin may be able to maintain cytoplasmic integrity independently of IFs. Literature Cited Colucci-Guyon, E., Porteir, I. Dunia, D. Paulin, S. Pourin, and C. Babinet. 1994. Mice lacking vimentin develop and repro- duce without an obvious phenotype. Cell 79: 679-694. Foisner, R., and G. Wiche. 1987. Structure and hydrodynamic prop- erties of plectin molecules. / Mol. Biol. 198: 515-531. Foisner, R., and G. Wiche. 1991. Intermediate filament-associated proteins. Curr. Opin. Cell Biol. 3: 75-81. McLean, W. H. I., L. Pulkkinen, F. J. D. Smith, E. L. Rugg, E. B. Lane, F. Bullrieh, R. E. Burgeson, S. Amano, D. Hudson, K. Owaribe, J. A. McGrath, J. R. McMillan, R. A. J. Eady, I. M. Leigh, A. M. Christiano, and J. Ditto. 1996. Loss of plectin causes epidermolysis bullosa with muscular dystrophy; cDNA clon- ing and genomic organization. Genes Devel. 10: 1724-1735. Smith, F. J. D., R. A. J. Eady, I. M. Leigh, J. R. McMillan, E. L. Rugg, D. P. Kelsell, S. P. Bryant, N. K. Spurr, J. F. Geddes, G. Kirtschig, G. Milana, A. G. de Bono, K. Owaribe, G. Wiche, L. Pulkltinen, J. Uitto, W. H. I. McLean, and E. B. Lane. 1996. Plectin deficiency results in muscular dystrophy with epidermolysis bullosa. Nature Genet. 13: 450-457. Svitkina, T. M., A. B. Verkhovsky, and G. G. Borisy. 1995. Im- proved procedures for electron microscopic visualization of the cy- toskeleton of cultured cells. J. Struct. Biol. 1
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