. The endocrine organs; an introduction to the study of internal secretion . -cally forms a separate in other animals theislets are closely encircled by and in contact with the alveolar tissue, andsometimes appear to be continued into it. According to Pensa, they have anabundant supply of nerve islet has a specialised blood-supply (fig. 89) in the form ofa network of irregular-shapedsinus-like capillaries which areboth larger and relatively morenumerous than the capillaries ofthe alveoli (Klihne and Lea). The cells of the islets aregenerally much less stained bythe ordina
. The endocrine organs; an introduction to the study of internal secretion . -cally forms a separate in other animals theislets are closely encircled by and in contact with the alveolar tissue, andsometimes appear to be continued into it. According to Pensa, they have anabundant supply of nerve islet has a specialised blood-supply (fig. 89) in the form ofa network of irregular-shapedsinus-like capillaries which areboth larger and relatively morenumerous than the capillaries ofthe alveoli (Klihne and Lea). The cells of the islets aregenerally much less stained bythe ordinary dyes used in histo-logy than are those of the are therefore usually de-scribed as chromophobe. Butthey have an especial affinity, asBensley has shown, for neutral red and janus green, employed as intravital stains. Although they containgranules, these are much finer than the zymogen granules of the alveolarcells. According to Lane, there are two kinds of cell in the islets, dis-tinguishable from one another by the nature of their granules. The cells ^ § ^. FIG. 89. — An islet of Langerhans of the pancreas,with its blood-vessels injected. (Kiihne and Lea.) The Internal Secretion of the Pancreas 127 come into very close relation—indeed, in actual contact—with the wallsof the blood capillaries. If the duct of the pancreas is tied, the ordinaryalveolar tissue disappears after a time, although for a long while there areremains of the ducts. But most observers are agreed that the islet tissuedoes not—at least to any great degree—participate in the atrophy of thealveoli, and the statement that it persists under these circumstances—although denied by some authors—is generally accepted. EFFECT OF SURGICAL REMOVAL OF PANCREAS. DIABETES Since the discovery in 1889 by v. Mering and Minkowski that removalof the pancreas, or even of the greater part of the organ, is immediatelyfollowed by hyperglycsemia leading to severe and fatal diabetes, whereasthis effect i
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