Transactions of the American Association of Obstetricians, Gynecologists, and Abdominal Surgeons for the year ... . ell and its surrounding fluid possess inter- and retroactiveproperties. The most convincing proof of this is given by Carrel,2who has grown connective tissue in vitro for almost eight years. Theplasmatic jelly medium, when used too long, became liquefied, itsfibrin disappeared and all the air rarefied, effecting a marked slowing ofgrowth. Fresh, unused plasma from the ice box promptly quickenedthe growth rate. The plasma from a chicken four to five months oldcaused a growth fifte
Transactions of the American Association of Obstetricians, Gynecologists, and Abdominal Surgeons for the year ... . ell and its surrounding fluid possess inter- and retroactiveproperties. The most convincing proof of this is given by Carrel,2who has grown connective tissue in vitro for almost eight years. Theplasmatic jelly medium, when used too long, became liquefied, itsfibrin disappeared and all the air rarefied, effecting a marked slowing ofgrowth. Fresh, unused plasma from the ice box promptly quickenedthe growth rate. The plasma from a chicken four to five months oldcaused a growth fifteen microns more extensive than did that from afive to six year old. The reactions following exhaustion, irritation and specific diet, giveacidity, toxicity, and cytoplasmic sensitization. Measurement of thesestates is a procedure of real scientific value to the clinician. TISSUE RESISTANCE TO CANCER 271 The reaction of connective tissue to epithelial neoplasia, before andafter its invasion, is significant and important. The increased cellu-larity, invasive and extensive growth, hypernutrition, diminished elas-. Fig. 5. Fig. 6. Fig. 5.—Basal-Called carcinoma. The new growth tissue is irregular in form and sharplydemarcated. The growth is very slow and the connective tissue resistance is high, controllingrapid extension. Fig. 6.—Scirrhous carcinoma of the stomach. Twenty years ago the patient developed car-cinoma of the mammary gland and submitted to a radical operation. Ten years later panhys-terectomy became necessary for carcinoma of the uterus. Ten years after this, symptoms ofcarcinoma of the stomach appeared. No operation was done for this condition. At autopsyneoplasia of the stomach, with marked extensive induration, was found. The photomicrograph exhibits an interesting involvement of the stomach muscularis. withatrophy, hyalinization, connective tissue increase and new growth epithelial cell infiltration. Illustrative of carcinomatous involvement, firstly in decidua
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