. The elements of pathological histology with special reference to practical methods . tter increasing in number and partly also in size, and thefibres becoming not only more numerous but thicker. There nextappear further changes which are undoubtedly of an inflammatorynature, viz., aggregations of leucocytes and sometimes also of redcorpuscles and grains of pigment in the perivascular spaces of thevessels of the cortex, and in many cases in those of the medullary MULTIPLE SCLEROSIS 343 centre also, together meninges with small-celled infiltrations in the innerwhich are either confined to the
. The elements of pathological histology with special reference to practical methods . tter increasing in number and partly also in size, and thefibres becoming not only more numerous but thicker. There nextappear further changes which are undoubtedly of an inflammatorynature, viz., aggregations of leucocytes and sometimes also of redcorpuscles and grains of pigment in the perivascular spaces of thevessels of the cortex, and in many cases in those of the medullary MULTIPLE SCLEROSIS 343 centre also, together meninges with small-celled infiltrations in the innerwhich are either confined to the immediate neighbour-hood of the blood-vessels or show a more diffuse distribution. Multiple cerebrospinal sclerosis is marked macroscopically by theoccurrence of more or less numerous grey or reddish-grey patches offirmer or softer consistence in the white and grey substance of thebrain and spinal cord (Fig. 167, a); and histologically, on the onehand by proliferative processes in the neuroglia and in the adventitiaof the vessels, on the other by atrophy of the nervous elements. If. Fig. 168.—Multiple Sclerosis of the Spinal Cord. A portion of the superficialparts of the right antero-lateral column. x 500. (Weigerts htematoxylin.) A,Normal part of the lateral column ; B, Sclei-otic part of the lateral column ; a, Nerve-fibres not yet degenerated, seen in section ; h, Granule cells, mostly in the immediateneighbourhood of the sheath of blood-vessels ; c, Thickened bands of neuroglia. somewhat younger and softer patches be examined, the sheath andadventitia of the blood-vessels (which latter are usually a littledilated) are found to be infiltrated with round cells and partiallyalso with granule cells (Fig. 168, I). Besides this the neurogliaforms a feltwork of fine shining fibres, which radiate out from thefrequently polynuclear neuroglia-cells, and still contain more orless numerous round cells entangled amongst them. Later, whenthe patches become firmer, the round cells disap
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Keywords: ., bookcentury1800, bookdecade1890, booksubjectpatholo, bookyear1895
