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Archive image from page 16 of The development of a cosmid. The development of a cosmid map of chromosome 12p13 . developmentofcos00belk Year: 1998 Genetic VS. Physical Maps. Genetic and physical maps of the genome are very different in the information they provide human genome project researchers. A genetic map describes the Hnear order of genes along a chromosome's length. Homologous chromosomes are really two copies of the same chromosome that are found in each cell. They carry differing allele combinations, or two copies of a given gene, which are distributed to the gametes during m
Archive image from page 16 of The development of a cosmid. The development of a cosmid map of chromosome 12p13 . developmentofcos00belk Year: 1998 Genetic VS. Physical Maps. Genetic and physical maps of the genome are very different in the information they provide human genome project researchers. A genetic map describes the Hnear order of genes along a chromosome's length. Homologous chromosomes are really two copies of the same chromosome that are found in each cell. They carry differing allele combinations, or two copies of a given gene, which are distributed to the gametes during meiosis. The different copies of the alleles lie at the same point on the homologous chromosomes. Studying recombination frequencies among differing genes on homologous chromosomes produces genetic maps; the more frequently recombination occurs between two genes, the farther apart they are positioned on the chromosome. The key is that crossing over frequency increases with distance. Two genes whose alleles are close together rarely separate by crossing over. Genes that are separated at a greater distance are separated more frequently (FIGURE 1).' A centimorgan, cM, is the term used to arbitrarily define the distance between two positions on a chromosome corresponding to a one-percent recombination frequency. This map unit designation is m honor of the geneticist Thomas Hunt Morgan.' REASSORTMENT OF LINKED GENES DURING RECOMBINATION
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