. A practical study of malaria. 2 9 28 14 4 2 2 Pulverized bark, sus-pended in water 2 3 4 9 6 3 1 With reference to the influence of food in the stomach upon the rate of absorption, Kleines400 experiments tend to show that quinine is much more slowly absorbed from a full than from a fasting stomach. The minute researches of Mariani prove, however, that, while the presence of food in the stomach TREATMENT 337 retards the absorption of quinine during the first-six hoursafter administration, the quantity absorbed during the entiretwenty-four hours after administration is greater from a fullthan
. A practical study of malaria. 2 9 28 14 4 2 2 Pulverized bark, sus-pended in water 2 3 4 9 6 3 1 With reference to the influence of food in the stomach upon the rate of absorption, Kleines400 experiments tend to show that quinine is much more slowly absorbed from a full than from a fasting stomach. The minute researches of Mariani prove, however, that, while the presence of food in the stomach TREATMENT 337 retards the absorption of quinine during the first-six hoursafter administration, the quantity absorbed during the entiretwenty-four hours after administration is greater from a fullthan from an empty stomach, and is absorbed in greater quan-tities even during the second and third days. He explainsthis by the theory that the liver is able to dispose of only asmall quantity of the alkaloid when it arrives together withthe products of digestion. Giemsa and Schaumann300 investigated the subject, with thefollowing results: After the administration of I gram ofquinine upon an empty stomach the excretion by the urine. Fig. 102.—Excretion of large doses of quinine (after Kleine). Quinine muriate, , by mouth, empty stomach. Quinine muriate, , in enema. Quinine muriate, , by mouth, three hours after eating. — . —. —. — Quinine muriate, , subcutaneously. during the first twenty-four hours reached per cent.; thesame amount administered during a meal was followed bythe excretion of per cent, during the first twenty-fourhours. The quantity excreted during three days after theadministration of 1 gram upon an empty stomach was cent.; during the same period following 1 gram at mealtime the quantity excreted was per cent. These investigators found that the elimination of quinineby the urine is about one-sixth greater when administered infive daily doses than in a single dose. The results of theirexperiments are thus tabulated: 22 338 THE STUDY OF MALARIA Table I One gram daily of quinine hydrochloride in water, at a single dose, bym
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Keywords: ., bookcentury1900, bookdecade1900, booksubjectmalaria, bookyear1909
