AMAarchives of neurology & psychiatry . TIOX OF SPIROCHETES TO XFRVE CELLS, XEUROGLL\CELLS .\ND EXUD-ATE Xo one has ever satisfactorily demonstrated that spirochetes existwithin nerve cells, although they may be grouped around nerve is (juestionable whether they have been seen in neuroglia cells. Theyhave sometimes been found among the cells of the exudate, but havenot been conclusivelv to lie within the cells themselves. DUXLAP—GEXERAL PARALYSIS 597 METHOD OF INCREASE OF SPIROCHETES IX GENERAL PARALYSISAND PATHWAYS BY WHICH THEY SPREAD Little is known concerning the method of
AMAarchives of neurology & psychiatry . TIOX OF SPIROCHETES TO XFRVE CELLS, XEUROGLL\CELLS .\ND EXUD-ATE Xo one has ever satisfactorily demonstrated that spirochetes existwithin nerve cells, although they may be grouped around nerve is (juestionable whether they have been seen in neuroglia cells. Theyhave sometimes been found among the cells of the exudate, but havenot been conclusivelv to lie within the cells themselves. DUXLAP—GEXERAL PARALYSIS 597 METHOD OF INCREASE OF SPIROCHETES IX GENERAL PARALYSISAND PATHWAYS BY WHICH THEY SPREAD Little is known concerning the method of increase of spirochetesin general paralysis. We know practically nothing of the rapidity ofprogression of spirochetes and the paths by which they travel. It isconsidered highly probable that they proliferate and spread locally inthe gray matter, but it is not likely that they are spread from place toplace in the brain to any great extent by the blood stream, or by thecerebrospinal fluid, for, with the exceptions previously ^ Fig. )parasites. —Localized massive girdling of the walls of blood vessels (Wall-by spirochetes and invasion of the walls of the vessels by the where postmortem migration is probable, they have never been seenwith the microscope in general paralysis in blood, cerebrospinal fluidor in the centrifugalized sediment of the fluid. \\e must remember, however, that in some instances animals havebeen reported as infected by injections of blood or of spinal fluid frompatients with general paralysis, though many investigators have alwaysfailed to obtain results by such injections. Jahnel himself thought hesucceeded with one rabbit after seven months of incubation, but hecould not keep the strain to study its characteristics. Aalente failedutterly in 103 animals, using puncture material from brains of living 598 ARC I IIIUS OF XEUROLOGV AM) PSVCIUATRY patients with general jjaralysis, also the blood and si)inal fluid. Tfjrsterand Thomascze
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