. Bulletin - United States National Museum. Science. thi stability. of a auclein. For preparing nuclein from yeasl cells, Felix Hoppe-Seylei I 1825 1895) described the following details: Yeast is dispersed in watei to extract soluble materials, like salts 01 sugars. Aftei .1 few bonis, the insoluble material is separated, washed once more with water, .uu\ then extracted with a ver) dilute solution of sodium hydroxide. I he slightly alkaline solution, treed from insoluble residues, is slowly added to a weak hydrochloric aeid. A pre- cipitate loi ins which is ,-(l In lilt rat ion, washe
. Bulletin - United States National Museum. Science. thi stability. of a auclein. For preparing nuclein from yeasl cells, Felix Hoppe-Seylei I 1825 1895) described the following details: Yeast is dispersed in watei to extract soluble materials, like salts 01 sugars. Aftei .1 few bonis, the insoluble material is separated, washed once more with water, .uu\ then extracted with a ver) dilute solution of sodium hydroxide. I he slightly alkaline solution, treed from insoluble residues, is slowly added to a weak hydrochloric aeid. A pre- cipitate loi ins which is ,-(l In lilt rat ion, washed with dilute aeid. then with eold alcohol, and imalK ex- tracted l>\ boiling alcohol ["he dried residue is the nuclein li contains six percent phosphorus. A little more washing with water, a slightl) [1 1 â in with a\ a living organism. With I'.. S. London, he introduced a solution of nucleic acid into, , the gastrointestinal segment ol a dog through a gastric fistula and with- drew the product of digestion through an intestinal fistula. Fortunately, the products obtained in such degradations were not new- in themselves. The carbohydrate in this nucleic acid proved to he identical with D-ribose, which Emil Fischei had artificially made from arabinose and named ribose to indicate this relationship (1891). The nitrogenous products ol the degradation were identical with Substances previously prepared in the long study of inn acid. In the course of this study, Emil Fischer established uric acid and a number of its derivatives as having the elementar\ skeleton of what he called "pure uric ; abbreviated to purine. Out of Adolf Baeyer's work on barbituric acid came the knowledge ol pyrimidine and its derivatives. From these findings, together with what Oswald Schmiedeberg (l!!:5r> 1921) had established conccrn-. M A. WuRT, Dictionnairi deChimie, supp. part 2, [| p. 1087; A ECOSSBL, £filschrijt fur pkysinlogische Chi erii I i 1 H7l»), p. 284. P
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