. The endocrine organs; an introduction to the study of internal secretion . r cent, havepermanent glycosuria, although alimentary glycosuria is not is present in about 11 per cent. The histological appearances (figs. 26, 27) are conformable with thetheory of a hypersecretion. The gland is greatly enlarged, and the indi-vidual vesicles are irregular and tend to run together. The interstitialtissue is increased in amount and assumes a lymphoid appearance, some-times with characteristic germinal centres. The follicle wall tends to growinto the interior of the conjoined follic
. The endocrine organs; an introduction to the study of internal secretion . r cent, havepermanent glycosuria, although alimentary glycosuria is not is present in about 11 per cent. The histological appearances (figs. 26, 27) are conformable with thetheory of a hypersecretion. The gland is greatly enlarged, and the indi-vidual vesicles are irregular and tend to run together. The interstitialtissue is increased in amount and assumes a lymphoid appearance, some-times with characteristic germinal centres. The follicle wall tends to growinto the interior of the conjoined follicles in the form of projections, thusincreasing the surface for secretion and giving the cavities a still moreirregular aspect. In some parts the follicles are smaller than usual, andmay even disappear. The cells lining the follicles tend to acquire acolumnar form: in later stages they may undergo degeneration and becomeset free within the follicles. The contents of the follicles are more fluidthan in the normal thyroid, and in sections show little or no FIG. —Case of exophthalmic goitre.(Byrom Bramwell.) 38 The Endocrine Organs Direct proof of hypersecretion of the thyroid is thought to be furnished
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