Saint Jerome in the Wilderness, 1475-1480. Saint Jerome (ca. 347-420), one of the four Latin Fathers of the Church (along with Saints Augustine, Ambrose, and Gregory the Great), is particularly famous for translating the Bible into Latin, known as the Vulgate Bible. The saint spent four years in the Syrian desert as a hermit, mortifying his flesh and elevating his spirit through study. The open book contains a passage from a letter attributed to Saint Augustine in which Jerome is compared to Saint John the Baptist, another saint who lived in the wilderness.

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